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Detalji

Kategorija: Blog (en-GB)

Objavljeno: 18 Studeni 2019

Djuro Josić, ID number f6340eaf-e1a0-46d8-937d-b868dd7b4d31

Dr. Djuro Josić just got retired as full professor at the University of Rijeka, Department of Biotechnology, where he was also Head of Division of Medicinal Chemistry and leader of the Laboratory for Analytical Biochemistry and Proteomics. Dr. Josic is now Full Professor Medicine (Research) at the Warren Alpert Medical School, Brown University in Providence, RI, USA . He is author of over 200 publications in peer reviewed journals such as J. Biol. Chem., Anal. Chem., Mol. Cell. Proteomics, BBA, General Subjects, Trends Anal. Chem., as well as several book chapters. He is the Editor of several books like Liver Proteomics, Methods and Protocols (Springer 2012) and Major Reference Work Foodomics for Food Safety (Elsevier 2020).  In last three years, Professor Josic gave more than ten invited lectures at the international scientific institutes and symposia, and together with his co-workers presented different lectures at international summer schools. Professor Josić also has more than 20 granted European and USA patents. He reviewed numerous manuscripts for high-ranking journals such as Nature (Methods), Anal. Chem., Biochemistry, Angew. Chemie, Int. Ed. at others, and he is also Editor and/or Member of Editorial Board of Curr. Opinion Food Sci., Electrophoresisis and Int. J. Proteomics.  His work was cited over 3500 times and has over 42,000 views (according to Elsevier’s data).  Professor Josic was the Supervisor for 10 postgraduate 19 graduate students, and he also supervised numerous master/bachelor degree students at Free (now Humboldt) University Berlin, Germany, Brown University, Universities of Vienna Ljubljana and the Universities in Zagreb and Rijeka.  He is member of several Biochemical, Chemical and Proteomic Societies, and also Secretary and one of the founders of the Croatian Proteomic Society. He was the organizer, chairman and member of the Scientific Committees of several international meetings. In the years 2016/2018, he was/is the Chairman of the International Summer School and Meeting Monoliths 2016 and 2018 (MSS 2016/2018) in Portorož, Slovenia. Professor Josic completed his training at the University of Zagreb and Technical University in Berlin, West, he got his Master Degree 1977 at the University of Zagreb, and his PhD in1981 at the Technical University in Berlin (West). He was Postdoctoral Fellow 1983/1985 at the National Institutes of Health, Bethesda, MD, USA. He finalized 12 grants in the USA, Austria, Germany and Croatia, including three Excellence Grants (COBRE CCRD) at the Rhode Island Hospital, Brown University for over 20 million dollars in 12 years (as Head of the Proteomics Core), and he is currently the Coordinator for the EU grant  "HTP-GlycoMet”, European Union (Euro 2.2 Mio, running over 4 years), that started October 1, 2013. Professor Josic performed pioneering work in development of protein separation, especially on separation of membrane proteins and other glycoproteins by use of different compatible chromatographic supports. Two early publications about the use of monolithic supports for separation of serum and membrane proteins as well as fast enzymatic conversion of low- and macromolecular substrates were cited for about 200 times. Recent work was focused on proteomic and glycomic investigations, and high-throughput isolation of high- and low abundant proteins from complex biological mixtures, and development of label-free quantitative proteomics.

Dr. Josić’s publications in last 5 years are:

1. Šrajer Gajdošik M, Kovač S, Malatesti N, Müller E, Josic D  Ion-Exchange Sample Displacement  Chromatography as a Method for Fast and Simple Isolation of Low- and High-Abundance Proteins from Complex Biological Mixtures. Food Technol. Biotechnol. (2014) 52 (1) 58–63.
2. Ivanišević Malčić A, Breen L, Josić Dj, Jukić Krmek S, Dzombeta T, Matijević J, Grgurević L, Pavelić K, Kruslin B, Kraljević Pavelić S Proteomics profiling of keratocystic odontogenic tumours reveals AIDA as novel biomarker candidate.   Oral. Pathol. Med. (2014)  doi 10.1111/jop12239
3. Lee Y-C, Srajer Gajdosik M,  Josic D, J.G. Clifton, Logothetis C, Lee L- YY, Gallick GE, Maity SN, Lin S-H: Secretome analysis of an osteogenic prostate tumor identifies complex signaling networks mediating cross-talk of cancer and stromal cells within the tumor microenvironment. Cell. Proteomics doi:10.1074/mcp. M114.039909, Dec 2014.
4. Rešetar D, Kraljevic-Pavelic S, Josic D (2015) Foodomics for investigations of food toxins. Curr Opin Food Sci http://dx.doi.or /10.1016/j.cofs. 2015.05.004 2214-7993.
5. Andjelković U, Martinović T, Josić Dj. (2015)  Foodomic investigations of food allergies. Opin. Food Science 4: 92-98.
6. Josić Dj, U Andjelković, Breen L, Dupuy D, Lauc G, Pučić Baković M, Vidič J  (2015) High-throughput analysis of plasma samples and determination of changes in glycomic patterns in the immunoglobulins of patients after image-guided tumor ablation. Glycoconjugate Journal 32 : 173-174.
7. Breen LD, Pučić-Banković M, Vučković F, Reiding KR, Trbojević-Akmačić I, Srajer-Gajdošik M, Cook, MI,  Lopez MJ, Wuhrer M, Camara LM, Andjelković U, Dupuy DE, Josić Dj (2016). IgG and IgMglycosylation patterns in patients undergoing image-guided tumor ablation. BBA - General Subjects1016/j.bbagen.2016.01.011. 
8. Martinović T, Andjelković U, Šrajer Gajdošek M, Rešetar D, Josić Dj. (2016)Foodborne pathogens and their toxins. Proteomics 147 (2016) 226-235 Doi: 10.1016/j.prot.201604.029.
9. Malatesti N, Harej A, Kraljević Pavelić S, Lončarić M, Zorc H, Wittine K, Andjelkovic U, Josic Dj. (2016) Synthesis, characterisation and in vitro investigation of photodynamic activity of 5-(4-octadecanamidophenyl)-10,15,20-tris(N-methylpyridinium-3-yl)porphyrin trichloride on HeLa cells using low light fluence rate. Photodyn.  Ther. 16: 115-126.
10. Josić Dj,  Andjelković (2016) The Role of Proteomics in Personalized Medicine. In: Personalized medicine: A New Medical and Social Challenge (Europeanization and Globalization), edited by N. Bodiroga-Vukobrat, D. Rukavina, K. Pavelić, G.G. Sander, Springer International.
11. Rešetar D, Martinović T, Kraljević Pavelić S. Andjelković U, Josić Dj (2016) Proteomics and peptidomics as tools for detection of food contamination by bacteria. In: Proteomics in Food, edited by F. Toldra & LML Nollet, Springer.
12. Josić Dj, Rešetar D, Peršurić Z, Martinović T, Kraljevic Pavelić S (2017): Detection of Microbial Toxins by -Omics Methods: A Growing Role of Proteomics, In: Proteomics in Food Science, edited by Michelle L. Colgrave, Academic Press, 485-506.
13. Andjelković U, Giacometti J, Josić Dj. (2017) Protein and peptide separations. In: Liquid chromatography, Volume 2, Applications. (eds.) Fanali S, Haddad PR, Poole CF, Riekkola M. pp 107-157.
14. Andjelković U, Gavrović-Jankulović M, Martinović T, Josić Dj. (2017) Omics methods as a tool for investigation of food allergies. Trends Anal. Chem. 96 (2017), 107-115 DOI: 10.1016/j.trac.2017.07.011
15. Martinović T, Josić Dj. (2017) Polymethacrylate-based monoliths as stationary phases for separation of biopolymers and immobilization of enzymes. Electrophoresis 38 (2017) 1527-1542.
16. Šrajer Gajdošik M, Andjelković U, Gašo-Sokač D, Pavlović H, Shevchuk O, Martinović T, Clifton J, Josić Dj (2017) Proteomic analysis of food borne pathogens following the mode of action of the disinfectants based on pyridoxal oxime derivatives. Res. Int. 99 (2017) 560-570. DOI: 10.1016/j.foodres.2017.06.016
17. Andjelković U, Šrajer Gajdošik M, Gašo-Sokač D, Martinović T and Josić Dj (2017) Foodomics and Food Safety: Where We Are. Food Tech Biotech 55 (3) DOI: 10.17113/ftb.55.03.17.5044
18. Martinović T, Andjelković U, Klobučar M, Černigoj U, Vidič J, Lučić M, Pavelić K, Josić D (2017) Affinity chromatography on monolithic supports for simultaneous and high-throughput isolation of immunoglobulins from human serum. Electrophoresis 38 (2017) 2909-2913. doi: 10.1002/elps.201700216.
19. Andjelković, U, Josić, D (2018) Mass spectrometry based proteomics as foodomics tool in research and assurance of food quality and safety. Trends Food Sci. & Technol. 77(2018) 100-119.   https://doi.org/10.1016/j.tifs.2018.04.008
20. Djuro Josic, Editor, Editorial, Special Issue Electrophoresis (Vol. 38, Issue 22-23) dedicted to monolithic supports, Electrophoresis 38, p. 2809.
21. Josić D, Peršurić Ž, Rešetar D, Martinović T, Saftić L, Kraljević Pavelić S: Use of Foodomics for Control of Food Processing and Assessing of Food Safety, In: Advances in Food and Nutrition Research, Elsevier, 81: 187-229.
22. Martinović T, Šrajer-Gajdošik, M, Josić D (2018) Sample preparation in foodomic analyses. Electrophoresis 39 (2018) 2821-2826.
23. Šrajer-Gajdošik, M., Hixson, D, Brilliant, K, Quin Yang, D, De Paepe, ME, Josic, D, Mills, D (2018) Soft agar-based selection of spontaneously transformed rat prostate epithelial cells with highly tumorigenic characteristics. Molecular Path. 105 (2018) 89-97.
24. Andjelković, U, Josić, D (2018) Mass spectrometry based proteomics as foodomics tool in research and assurance of food quality and safety. Trends Food Sci. & Technol. 77(2018) 100-119.   https://doi.org/10.1016/j.tifs.2018.04.008
25. Josić, D, Martinović, T, Pavelic, K (2018) Protein glycosylation and metastases. Electrophoresis 40 (2019) https://doi.org/10.1002/elps.201800238
26. Josić, Dj. Kraljević Pavelić, S. (Eds) Foodomics and Food Safety(2019) Major Reference Work Comprehensive Foodomics.
27. Josić, Dj. Introductory, Foodomics and Food Safety (2019), Major Reference Work Comprehensive Foodomics, Elsevier, accepted.
28. Josić, Dj. Food safety, Foodomics and Food Safety (2019), Major Reference Work Comprehensive Foodomics, Elsevier, accepted.
29. Šrajer Gajdošik M, Andjelković U, Gašo-Sokač D, Pavlović H, Shevchuk O, Martinović T, Clifton J, Josić Dj. (2019) Proteomic changes in food borne pathogen Listeria monocitogenes following the inhibition with pyridoxal oxime derivatives. Res. Int. submitted.

Detalji

Kategorija: Blog (en-GB)

Objavljeno: 18 Studeni 2019

Elitza Petkova Markova-Car (ORCID ID: https://orcid.org/0000-0001-6979-0731; https://www.researchgate.net/profile/Elitza_Markova-Car)

Elitza Petkova Markova-Car is Asociate professor at the University of Rijeka, Department of Biotechnology in Croatia. She obtained Japanese Government Monbusho Scholarship for PhD Student position at Kobe University, Japan and she received her PhD in Molecular Cellular Science from Kobe University, Japan. She was senior research assistant at Department of Histology and Embryology, Medical Faculty of Rijeka in a group of Prof. Stipan Jonjić where she focused on investigating the role of immunoevasion genes during chronic cytomegalovirus infection using molecular methods. She has authored 14 scientific publications in peer-reviewed journals including high-impact journals such as The Journal of Clinical Investigation, European Journal of Medicinal Chemistry, and two book chapters. Her work has been cited 226 times (h-index 7; i10-index 5). She was a reviewer for several international peer-reviewed scientific journals such as OncoTargets and Therapy, Tumor Biology, and Integrative Cancer Therapies. She has supervised six MSc theses and is currently supervising two PhD students. She has participated in two Japanese scientific projects (Grant-in-aid for scientific research No.11460021, PI Prof. Makio Takeda, Ministry of Science, Sport and Culture of Japan from 2000-2003, and Research for the Future Program of JSPS No.99L01205, PI Prof. Makio Takeda, Japan Society for the Promotion of Science from 2000-2003), and 3 national projects: High throughput analytical platforms for Adriatic-brand food quality and authenticity, Croatian science foundation from 2012-2015, Molecular mechanisms of immune evasion by cytomegalovirus, Project ID: 062-0621261-1263, Ministry of Science, Education and Sports of Croatia from 2007-2009, and NK cell receptor regulation mediated by herpes viruses, Project ID: 0062004, Ministry of Science, Education and Sports of Croatia from 2005-2006. She is currently a collaborator on the project funded by the Croatian science foundation No.7500 “Immunological and regenerative implications of corrosion of dental materials in children and adolescents” (IMUNODENT) (2015-2019) led by Associate prof. Stjepan Špalj from School of Medicine, University of Rijeka, and collaborator on project funded by the Croatian Science Foundation No. 2018-01 3900 “Dissecting the mechanisms of therapy resistance in BRAF-mutant colon cancer using an integrated –omics approach” (2019 – 2023) led by Associate prof. Mirela Sedić from University of Rijeka, Department of biotechnology. She is the PI of the University of Rijeka research grant No. uniri-biomed-18-257 1426 “Circadian genes in laryngeal squamous cell carcinoma”. The main research interests of Dr. Markova-Car include molecular mechanisms of circadian rhythms, the role of clock genes in pathogenesis of malignancies and other diseases (melanoma, laryngeal squamous cell carcinoma, and ischemic heart disease), genetic analysis, SNP analysis, and SNP genotyping.

Dr Markova-Car’s publications over the last 5 years: 

1. Grbčić P, Car EPM, Sedić M. Targeting Ceramide Metabolism in Hepatocellular Carcinoma: New Points for Therapeutic Intervention. Curr Med Chem. 2019. doi: 10.2174/0929867326666190911115722. The first two authors contributed equally to this paper
2. Pavelić SK, Markova-Car E, Klobučar M, Sappe L, Spaventi R. Technological Advances in Preclinical Drug Evaluation: the Role of -Omics Methods. Curr Med Chem. 2019. doi: 10.2174/0929867326666190711122819.
3. Peršić V, Raljević D, Markova-Car E, Cindrić L, Miškulin R, Žuvić M, Kraljević Pavelić S. Vitamin D-binding protein (rs4588) T/T genotype is associated with anteroseptal myocardial infarction in coronary artery disease patients. Ann Transl Med. 2019; 7(16):374.
4. Rahman S, Kraljević Pavelić S, Markova-Car E. Circadian (De)regulation in Head and Neck Squamous Cell Carcinoma. Int J Mol Sci. 2019; 20(11). pii: E2662.
5. Sović I, Jambon S, Kraljević Pavelić S, Markova-Car E, Ilić N, Depauw S, David-Cordonnier MH, Karminski-Zamola G. Synthesis, antitumor activity and DNA binding features of benzothiazolyl and benzimidazolyl substituted isoindolines. Bioorg Med Chem. 2018; 26(8):1950-1960.
6. Franzoni A, Markova-Car E, Dević-Pavlić S, Jurišić D, Puppin C, Mio C, De Luca M, Petruz G, Damante G, Pavelić SK. A polymorphic GGC repeat in the NPAS2 gene and its association with melanoma. Exp Biol Med (Maywood). 2017; 242:1553-1558. The first two authors contributed equally to this paper
7. Bujak M, Ratkaj I, Markova-Car E, Jurišić D, Horvatić A, Vučinić S, Lerga J, Baus-Lončar M, Pavelić K, Kraljević Pavelić S. Inflammatory Gene Expression Upon TGF-β1-Induced p38 Activation in Primary Dupuytren's Disease Fibroblasts. Front Mol Biosci. 2015; 2:68.
8. Čengić T, Trkulja V, Kraljević Pavelić S, Ratkaj I, Markova-Car E, Mikolaučić M, Kolundžić R, Association of TGFB1 29C/T and IL6 -572G/C polymorphisms with developmental hip dysplasia: a case–control study in adults with severe osteoarthritis. Int Orthop. 2015; 39:793-798.
9. Sović I, Kraljević Pavelić S, Markova-Car E, Ilić N, Nhili R, Depauw S, David-Cordonnier MH, Karminski-Zamola G. Novel Phenyl and Pyridyl Substituted Derivatives of Isoindolines: Synthesis, Antitumor Activity and DNA binding features. Eur J Med Chem.2014; 87:372-385.
10. Markova-Car EP, Jurišić D, Ilić N, Kraljević Pavelić S. Running for time: circadian rhythms and melanoma. Tumour Biol. 2014; 35(9):8359-68.

Detalji

Kategorija: Blog (en-GB)

Objavljeno: 18 Studeni 2019

Thomas Oliver Eichmann, (ORCID-ID: 0000-0002-8521-2795, SCOPUS-ID: 55934314500) Mag. Dr. rer. nat. Thomas Eichmann is university assistant, Scientific Director of the Core Facility Mass Spectrometry, and Head of the Center for Explorative Lipidomics at the Institute of Molecular Biosciences at the University of Graz. He has been extensively trained in mass spectrometry of lipids and small molecules over the past 7 years in a highly renowned group in the field of energy and lipid metabolism. He has authored 55 scientific publications in peer-reviewed journals including high-impact journals such as Nature Medicine, Nature Chemical Biology, Cell Metabolism, and Nature Communications, 1 book chapters, and 1 encyclopaedia entry. His work has been cited 1964 times (h-index 17). He supervised 4 master students and co-supervised several PhD, MSc, and BSc theses. He is lecturer and course leader of 3 courses for undergraduate chemistry and graduate biochemistry students at the Institutes of Chemistry and Molecular Biosciences, respectively, at the University of Graz. As Head of the Core Facility Mass Spectrometry he is one of the main collaborative partners for all projects including lipid mass spectrometry within the Institute of Molecular Biosciences at the University of Graz as well as the Medical University of Graz and the Technical University of Graz. His strong focus on ceramide and sphingolipid research started with the project funded by the
Austrian science foundation No. P24944 “The function of CGI-58 in the development of the skin barrier” led by Prof. Günter Haemmerle, PhD and is now continued by the project No. P25944 “The function of PNPLA1 in skin lipid metabolism” led by Franz Radner, PhD from the Institute of Molecular Biosciences at University of Graz, both focusing on sphingolipid/ceramide metabolism in rare, genetic skin disorders. Within the Center for Explorative Lipidomics (CEL) the main research interests of Dr. Eichmann include SFC and LC-IM-MS method development and MS-based lipidomic investigations of metabolic, rare, and chronic diseases, like type 2 diabetes, ichthyosis, and cancer, including identification, isolation, and quantification of possibly bioactive lipid species and the validation of biomarkers. This endeavour is currently supported by a cooperative project with Agilent Technologies. Since 2019 the CEL is an Agilent reference laboratory for application of ion-mobility mass spectrometry in lipidomics. 

A versatile ultra-high performance LC-MS method for lipid profiling. Knittelfelder OL, Weberhofer BP, Eichmann TO, Kohlwein SD, Rechberger G, Journal of Chromatography B, doi: 10.1016/j.jchromb.2014.01.011 IF: 2,72

Growth retardation, impaired triacylglycerol catabolism, hepatic steatosis, and lethal skin barrier defect in mice lacking comparative gene identification-58 (CGI-58). Radner FP, Streith IE, Schoiswohl G, Schweiger M, Kumari M, Eichmann TO, Rechberger G, Koefeler HC, Eder S, Schauer S, Theussl HC, Preiss-Landl K, Lass A, Zimmermann R, Hoefler G, Zechner R, Haemmerle G. J. Biol. Chem. doi: 10.1074/jbc.M109.081877 IF: 4,57

ATGL-mediated fat catabolism regulates cardiac mitochondrial function via PPAR-α and PGC-1. Haemmerle G, Moustafa T, Woelkart G, Büttner S, Schmidt A, van de Weijer T, Hesselink M, Jaeger D, Kienesberger PC, Zierler K, Schreiber R, Eichmann TO, Kolb D, Kotzbeck P, Schweiger M, Kumari M, Eder S, Schoiswohl G, Wongsiriroj N, Pollak NM, Radner FP, Preiss-Landl K, Kolbe T, Rülicke T, Pieske B, Trauner M, Lass A, Zimmermann R, Hoefler G, Cinti S, Kershaw EE, Schrauwen P, Madeo F, Mayer B, Zechner R., Nat. Med. doi: 10.1038/nm.2439 IF: 27,36

Studies on the substrate and stereo/regioselectivity of adipose triglyceride lipase, hormone- sensitive lipase, and diacylglycerol-O-acyltransferases. Eichmann TO, Kumari M, Haas JT, Farese RV Jr., Zimmermann R, Lass A, Zechner R, J. Biol. Chem.
doi: 10.1074/jbc.M112.400416 IF: 4,57

Metabolic disease and ABHD6 alter circulating bis(monacylglycerol)phosphate profile in mice and humans. Grabner F, Fawzy N, Pribasnig MA, Trieb M, TaschlerU, Holzer M, Schweiger M, Wolinski H, Kolb D, Horvath A, Breinbauer R, Rülicke T, Rabl R, Lass A, Stadlbauer V, Hutter-Paier B, Stauber RE, Fickert P, Zechner R, Marsche G, Eichmann TO, Zimmermann R. J. Lipid Res. doi: 10.1194/jlr.M093351 IF: 5.559 (corresponding author)

Development and characterization of small molecule inhibitors for adipose triglyceride lipase. Mayer N, Schweiger M, Romauch M, Eichmann TO, Ivkovic J, Fuchs E, Mrak I, Grabner GF, Lass A, Höfler G, Zechner R, Zimmermann R, Breinbauer R, Nat. Chem. Biol. doi: 10.1038/nchembio IF: 12,99

A novel mechanism for the biogenesis of outer membrane vesicles in Gram-negative bacteria. Roier S, Zingl F, Cakar F, Durakovic S, Kohl P, Eichmann TO, Klug L, Gadermaier B, Weinzerl K, Prassl R, Lass A, Daum G, Reidl J, Feldman M, Schild S. Nat. Commun. doi: 10.1038/ncomms10515 IF: 11,47