Thomas Oliver Eichmann, (ORCID-ID: 0000-0002-8521-2795, SCOPUS-ID: 55934314500) Mag. Dr. rer. nat. Thomas Eichmann is university assistant, Scientific Director of the Core Facility Mass Spectrometry, and Head of the Center for Explorative Lipidomics at the Institute of Molecular Biosciences at the University of Graz. He has been extensively trained in mass spectrometry of lipids and small molecules over the past 7 years in a highly renowned group in the field of energy and lipid metabolism. He has authored 55 scientific publications in peer-reviewed journals including high-impact journals such as Nature Medicine, Nature Chemical Biology, Cell Metabolism, and Nature Communications, 1 book chapters, and 1 encyclopaedia entry. His work has been cited 1964 times (h-index 17). He supervised 4 master students and co-supervised several PhD, MSc, and BSc theses. He is lecturer and course leader of 3 courses for undergraduate chemistry and graduate biochemistry students at the Institutes of Chemistry and Molecular Biosciences, respectively, at the University of Graz. As Head of the Core Facility Mass Spectrometry he is one of the main collaborative partners for all projects including lipid mass spectrometry within the Institute of Molecular Biosciences at the University of Graz as well as the Medical University of Graz and the Technical University of Graz. His strong focus on ceramide and sphingolipid research started with the project funded by the
Austrian science foundation No. P24944 “The function of CGI-58 in the development of the skin barrier” led by Prof. Günter Haemmerle, PhD and is now continued by the project No. P25944 “The function of PNPLA1 in skin lipid metabolism” led by Franz Radner, PhD from the Institute of Molecular Biosciences at University of Graz, both focusing on sphingolipid/ceramide metabolism in rare, genetic skin disorders. Within the Center for Explorative Lipidomics (CEL) the main research interests of Dr. Eichmann include SFC and LC-IM-MS method development and MS-based lipidomic investigations of metabolic, rare, and chronic diseases, like type 2 diabetes, ichthyosis, and cancer, including identification, isolation, and quantification of possibly bioactive lipid species and the validation of biomarkers. This endeavour is currently supported by a cooperative project with Agilent Technologies. Since 2019 the CEL is an Agilent reference laboratory for application of ion-mobility mass spectrometry in lipidomics.
A versatile ultra-high performance LC-MS method for lipid profiling. Knittelfelder OL, Weberhofer BP, Eichmann TO, Kohlwein SD, Rechberger G, Journal of Chromatography B, doi: 10.1016/j.jchromb.2014.01.011 IF: 2,72
Growth retardation, impaired triacylglycerol catabolism, hepatic steatosis, and lethal skin barrier defect in mice lacking comparative gene identification-58 (CGI-58). Radner FP, Streith IE, Schoiswohl G, Schweiger M, Kumari M, Eichmann TO, Rechberger G, Koefeler HC, Eder S, Schauer S, Theussl HC, Preiss-Landl K, Lass A, Zimmermann R, Hoefler G, Zechner R, Haemmerle G. J. Biol. Chem. doi: 10.1074/jbc.M109.081877 IF: 4,57
ATGL-mediated fat catabolism regulates cardiac mitochondrial function via PPAR-α and PGC-1. Haemmerle G, Moustafa T, Woelkart G, Büttner S, Schmidt A, van de Weijer T, Hesselink M, Jaeger D, Kienesberger PC, Zierler K, Schreiber R, Eichmann TO, Kolb D, Kotzbeck P, Schweiger M, Kumari M, Eder S, Schoiswohl G, Wongsiriroj N, Pollak NM, Radner FP, Preiss-Landl K, Kolbe T, Rülicke T, Pieske B, Trauner M, Lass A, Zimmermann R, Hoefler G, Cinti S, Kershaw EE, Schrauwen P, Madeo F, Mayer B, Zechner R., Nat. Med. doi: 10.1038/nm.2439 IF: 27,36
Studies on the substrate and stereo/regioselectivity of adipose triglyceride lipase, hormone- sensitive lipase, and diacylglycerol-O-acyltransferases. Eichmann TO, Kumari M, Haas JT, Farese RV Jr., Zimmermann R, Lass A, Zechner R, J. Biol. Chem.
doi: 10.1074/jbc.M112.400416 IF: 4,57
Metabolic disease and ABHD6 alter circulating bis(monacylglycerol)phosphate profile in mice and humans. Grabner F, Fawzy N, Pribasnig MA, Trieb M, TaschlerU, Holzer M, Schweiger M, Wolinski H, Kolb D, Horvath A, Breinbauer R, Rülicke T, Rabl R, Lass A, Stadlbauer V, Hutter-Paier B, Stauber RE, Fickert P, Zechner R, Marsche G, Eichmann TO, Zimmermann R. J. Lipid Res. doi: 10.1194/jlr.M093351 IF: 5.559 (corresponding author)
Development and characterization of small molecule inhibitors for adipose triglyceride lipase. Mayer N, Schweiger M, Romauch M, Eichmann TO, Ivkovic J, Fuchs E, Mrak I, Grabner GF, Lass A, Höfler G, Zechner R, Zimmermann R, Breinbauer R, Nat. Chem. Biol. doi: 10.1038/nchembio IF: 12,99
A novel mechanism for the biogenesis of outer membrane vesicles in Gram-negative bacteria. Roier S, Zingl F, Cakar F, Durakovic S, Kohl P, Eichmann TO, Klug L, Gadermaier B, Weinzerl K, Prassl R, Lass A, Daum G, Reidl J, Feldman M, Schild S. Nat. Commun. doi: 10.1038/ncomms10515 IF: 11,47